綜上所述,本研究從細(xì)胞水平初步探討了大黃素對(duì)模擬冷缺血再灌注后肝細(xì)胞內(nèi)鈣離子濃度及凋亡的影響,提示大黃素有可能通過抑制細(xì)胞內(nèi)鈣超載及細(xì)胞凋亡,從而減輕肝細(xì)胞冷缺血再灌注損傷,為其在臨床肝移植中的應(yīng)用提供一定的實(shí)驗(yàn)依據(jù)。
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